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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Rubiscoline</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><p>Die <b>Rubiscoline</b> sind eine Gruppe von <a href="Opioidpeptid" class="mw-redirect" title="Opioidpeptid">Opioidpeptiden</a>, die bei der <a href="Verdauung" title="Verdauung">Verdauung</a> des <a href="Protein" title="Protein">Proteins</a> Ribulose-1,5-bisphosphat-carboxylase/-oxygenase (<a href="Rubisco" class="mw-redirect" title="Rubisco">RuBisCo</a>) von <a href="Spinat" title="Spinat">Spinatblättern</a> entsteht.
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<div class="mw-heading mw-heading2"><h2 id="Wirkungsweise">Wirkungsweise</h2></div>
<p>Die Rubiscoline imitieren die Effekte von <a href="Opioid" class="mw-redirect" title="Opioid">Opioiden</a>, weshalb sie psychisch aktiv sind. Sie sind den Gluten-Exorphinen (<a href="Gliadorphin" title="Gliadorphin">Gliadorphine</a>) sehr ähnlich. Ihr Einfluss auf die psychische Verfassung ist noch nicht vollständig geklärt, beziehungsweise wird er sehr kontrovers diskutiert (siehe <a href="Gfcf-Ern%C3%A4hrung" title="Gfcf-Ernährung">Gfcf-Ernährung</a>). Die Rubiscoline binden an den <a href="Opioidrezeptor" class="mw-redirect" title="Opioidrezeptor">δ-Opioidrezeptor</a> und haben einen <a href="Analgetikum" title="Analgetikum">analgetischen</a> (schmerzlindernden) Effekt.<sup id="cite_ref-pmid11741591_1-0" class="reference"><a href="#cite_note-pmid11741591-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Zudem stimulieren sie die <a href="Ged%C3%A4chtnisbildung" class="mw-redirect" title="Gedächtnisbildung">Gedächtnisbildung</a>.<sup id="cite_ref-pmid12668220_2-0" class="reference"><a href="#cite_note-pmid12668220-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> 2007 wurden im <a href="Modellorganismus" title="Modellorganismus">Tiermodell</a> <a href="Anxiolytikum" title="Anxiolytikum">angstlösende</a> Eigenschaften von Rubiscolin-6 festgestellt.<sup id="cite_ref-pmid17766012_3-0" class="reference"><a href="#cite_note-pmid17766012-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>
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<div class="mw-heading mw-heading2"><h2 id="Typen_der_Rubiscoline">Typen der Rubiscoline</h2></div>
<p>Bisher sind zwei Typen von Rubiscolinen bekannt.
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<div class="mw-heading mw-heading3"><h3 id="Rubiscolin-5">Rubiscolin-5</h3></div>
<ul><li>Peptidsequenz: H-<a href="Glycin" title="Glycin">Gly</a>-<a href="Tyrosin" title="Tyrosin">Tyr</a>-Tyr-<a href="Prolin" title="Prolin">Pro</a>-OH</li>
<li>Summenformel: C<sub>30</sub>H<sub>45</sub>N<sub>5</sub>O<sub>9</sub></li>
<li><a href="Molare_Masse" title="Molare Masse">Molare Masse</a>: 619,70 g·mol<sup>−1</sup></li></ul>
<div class="mw-heading mw-heading3"><h3 id="Rubiscolin-6">Rubiscolin-6</h3></div>
<ul><li>Peptidsequenz: H-Gly-Tyr-Tyr-Pro-<a href="Threonin" title="Threonin">Thr</a>-OH</li>
<li>Summenformel: C<sub>39</sub>H<sub>54</sub>N<sub>6</sub>O<sub>10</sub></li>
<li>Molare Masse: 766,87 g·mol<sup>−1</sup></li></ul>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-pmid11741591-1"><span class="mw-cite-backlink"><a href="#cite_ref-pmid11741591_1-0">↑</a></span> <span class="reference-text">Yang S, u. a.: <cite style="font-style:italic">Rubiscolin, a delta selective opioid peptide derived from plant Rubisco</cite>. In: <cite style="font-style:italic"><a href="FEBS_Lett" class="mw-redirect" title="FEBS Lett">FEBS Lett</a>.</cite> 509. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>2</span>, 2001, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>213–7</span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/11741591?dopt=Abstract">PMID 11741591</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Rubiscoline&rft.atitle=Rubiscolin%2C+a+delta+selective+opioid+peptide+derived+from+plant+Rubisco&rft.au=Yang+S%2C+u.+a.&rft.date=2001&rft.genre=journal&rft.issue=2&rft.jtitle=FEBS+Lett.&rft.pages=213-7&rft.pmid=11741591&rft.volume=509.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-pmid12668220-2"><span class="mw-cite-backlink"><a href="#cite_ref-pmid12668220_2-0">↑</a></span> <span class="reference-text">Yang S, Kawamura Y, Yoshikawa M: <cite style="font-style:italic">Effect of rubiscolin, a delta opioid peptide derived from Rubisco, on memory consolidation</cite>. In: <cite style="font-style:italic"><a href="Peptides" title="Peptides">Peptides</a></cite>. 24. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>2</span>, 2003, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>325–8</span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/12668220?dopt=Abstract">PMID 12668220</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Rubiscoline&rft.atitle=Effect+of+rubiscolin%2C+a+delta+opioid+peptide+derived+from+Rubisco%2C+on+memory+consolidation&rft.au=Yang+S%2C+Kawamura+Y%2C+Yoshikawa+M&rft.date=2003&rft.genre=journal&rft.issue=2&rft.jtitle=Peptides&rft.pages=325-8&rft.pmid=12668220&rft.volume=24.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-pmid17766012-3"><span class="mw-cite-backlink"><a href="#cite_ref-pmid17766012_3-0">↑</a></span> <span class="reference-text">Hirata H, Sonoda S, Agui S, Yoshida M, Ohinata K, Yoshikawa M: <cite style="font-style:italic">Rubiscolin-6, a delta opioid peptide derived from spinach Rubisco, has anxiolytic effect via activating sigma<sub>1</sub> and dopamine D<sub>1</sub> receptors</cite>. In: <cite style="font-style:italic">Peptides</cite>. 28. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>10</span>, 2007, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>1998–2003</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.peptides.2007.07.024">10.1016/j.peptides.2007.07.024</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17766012?dopt=Abstract">PMID 17766012</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Rubiscoline&rft.atitle=Rubiscolin-6%2C+a+delta+opioid+peptide+derived+from+spinach+Rubisco%2C+has+anxiolytic+effect+via+activating+sigma1+and+dopamine+D1+receptors&rft.au=Hirata+H%2C+Sonoda+S%2C+Agui+S%2C+...&rft.date=2007&rft.doi=10.1016%2Fj.peptides.2007.07.024&rft.genre=journal&rft.issue=10&rft.jtitle=Peptides&rft.pages=1998-2003&rft.pmid=17766012&rft.volume=28.+Jahrgang" style="display:none"> </span></span>
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<div class="mw-heading mw-heading2"><h2 id="Literatur">Literatur</h2></div>
<ul><li>S. Doltsinis, W. Andlauer: <i>Alternativen zu tierischen Proteinen: Schlüsselkomponenten der Nahrung.</i> In: <i>Chemie in unserer Zeit</i>, 38/2004, S. 182–9.</li></ul>
<div class="mw-heading mw-heading2"><h2 id="Siehe_auch">Siehe auch</h2></div>
<ul><li><a href="Exorphin" class="mw-redirect" title="Exorphin">Exorphin</a></li>
<li><a href="Casomorphin" title="Casomorphin">Casomorphin</a></li>
<li><a href="Gliadorphin" title="Gliadorphin">Gliadorphin</a></li></ul></div><!--htdig_noindex--><div><div class="zim-footer">
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